| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydropyrimidine dehydrogenase [NADP(+)] |
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| Ligand | BDBM50124205 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_53186 |
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| IC50 | 200±n/a nM |
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| Citation |  Hattori, K; Kohchi, Y; Oikawa, N; Suda, H; Ura, M; Ishikawa, T; Miwa, M; Endoh, M; Eda, H; Tanimura, H; Kawashima, A; Horii, I; Ishitsuka, H; Shimma, N Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine. Bioorg Med Chem Lett13:867-72 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydropyrimidine dehydrogenase [NADP(+)] |
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| Name: | Dihydropyrimidine dehydrogenase [NADP(+)] |
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| Synonyms: | DHPDHase | DPD | DPYD | DPYD_HUMAN | Dihydropyrimidine dehydrogenase | Dihydropyrimidine dehydrogenase [NADP+] | Dihydrothymine dehydrogenase | Dihydrouracil dehydrogenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 111404.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_53186 |
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| Residue: | 1025 |
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| Sequence: | MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE
KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD
QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG
DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL
KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ
NVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS
VNPVC
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| BDBM50124205 |
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| n/a |
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| Name | BDBM50124205 |
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| Synonyms: | 2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile | CHEMBL443038 |
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| Type | Small organic molecule |
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| Emp. Form. | C5H3N3O2 |
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| Mol. Mass. | 137.0962 |
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| SMILES | O=c1[nH]cc(C#N)c(=O)[nH]1 |
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| Structure | 
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