Reaction Details |
| Report a problem with these data |
Target | GTPase KRas |
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Ligand | BDBM50561645 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2075593 (CHEMBL4731127) |
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Kd | 430±n/a nM |
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Citation | Ng, S; Juang, YC; Chandramohan, A; Kaan, HYK; Sadruddin, A; Yuen, TY; Ferrer-Gago, FJ; Lee, XC; Liew, X; Johannes, CW; Brown, CJ; Kannan, S; Aronica, PG; Berglund, NA; Verma, CS; Liu, L; Stoeck, A; Sawyer, TK; Partridge, AW; Lane, DP De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits. ACS Med Chem Lett11:1993-2001 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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GTPase KRas |
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Name: | GTPase KRas |
Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
Type: | PROTEIN |
Mol. Mass.: | 21656.10 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1476955 |
Residue: | 189 |
Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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BDBM50561645 |
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n/a |
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Name | BDBM50561645 |
Synonyms: | CHEMBL4760058 |
Type | Small organic molecule |
Emp. Form. | C100H160N28O27 |
Mol. Mass. | 2186.5118 |
SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@]1(C)CCC\C=C\CCC[C@](C)(NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(N)=O |r,t:67| |
Structure |
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