| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Ligand | BDBM50124513 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_162279 |
|---|
| Ki | 870.0±n/a nM |
|---|
| Citation |  Larsen, SD; Stevens, FC; Lindberg, TJ; Bodnar, PM; O'Sullivan, TJ; Schostarez, HJ; Palazuk, BJ; Bleasdale, JE Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activity. Bioorg Med Chem Lett13:971-5 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 49963.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant GST-fusion PTP1B (1-435). |
|---|
| Residue: | 435 |
|---|
| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
|
|
|
|---|
| BDBM50124513 |
|---|
| n/a |
|---|
| Name | BDBM50124513 |
|---|
| Synonyms: | 2-Carboxymethoxy-5-[(S)-2-pentylcarbamoyl-2-((S)-2-phenoxycarbonylamino-3-phenyl-propionylamino)-ethyl]-benzoic acid | CHEMBL369818 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H37N3O9 |
|---|
| Mol. Mass. | 619.6616 |
|---|
| SMILES | CCCCCNC(=O)[C@H](Cc1ccc(OCC(O)=O)c(c1)C(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)Oc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
