Reaction Details |
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Target | Glutamate receptor ionotropic, NMDA 2B |
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Ligand | BDBM50124908 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_141157 (CHEMBL749675) |
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Ki | 5.7±n/a nM |
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Citation | Claiborne, CF; McCauley, JA; Libby, BE; Curtis, NR; Diggle, HJ; Kulagowski, JJ; Michelson, SR; Anderson, KD; Claremon, DA; Freidinger, RM; Bednar, RA; Mosser, SD; Gaul, SL; Connolly, TM; Condra, CL; Bednar, B; Stump, GL; Lynch, JJ; Macaulay, A; Wafford, KA; Koblan, KS; Liverton, NJ Orally efficacious NR2B-selective NMDA receptor antagonists. Bioorg Med Chem Lett13:697-700 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Glutamate receptor ionotropic, NMDA 2B |
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Name: | Glutamate receptor ionotropic, NMDA 2B |
Synonyms: | GRIN2B | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Glutamate [NMDA] receptor subunit epsilon-2 | N-methyl D-aspartate receptor subtype 2B | N-methyl-D-aspartate receptor subunit 3 | NMDAR2B | NMDE2_HUMAN | NR3 | hNR3 |
Type: | PROTEIN |
Mol. Mass.: | 166375.46 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1438829 |
Residue: | 1484 |
Sequence: | MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
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BDBM50124908 |
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n/a |
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Name | BDBM50124908 |
Synonyms: | CHEMBL159560 | N-(2-Methoxy-benzyl)-4-trifluoromethoxy-benzamidine |
Type | Small organic molecule |
Emp. Form. | C16H15F3N2O2 |
Mol. Mass. | 324.2977 |
SMILES | COc1ccccc1CN=C(N)c1ccc(OC(F)(F)F)cc1 |w:9.9| |
Structure |
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