Reaction Details |
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Target | Queuine tRNA-ribosyltransferase |
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Ligand | BDBM50125765 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_225394 (CHEMBL847432) |
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Ki | 8100±n/a nM |
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Citation | Brenk, R; Naerum, L; Grädler, U; Gerber, HD; Garcia, GA; Reuter, K; Stubbs, MT; Klebe, G Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis. J Med Chem46:1133-43 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Queuine tRNA-ribosyltransferase |
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Name: | Queuine tRNA-ribosyltransferase |
Synonyms: | TGT_ZYMMO | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase (TGT) | tgt |
Type: | Protein |
Mol. Mass.: | 42844.19 |
Organism: | Zymomonas mobilis |
Description: | P28720 |
Residue: | 386 |
Sequence: | MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEE
GVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAK
RSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEM
FRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPI
NIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQK
IRDSISEGRFSQFAQDFRARYFARNS
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BDBM50125765 |
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n/a |
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Name | BDBM50125765 |
Synonyms: | 3-Amino-6-hydroxy-2-(2-hydroxy-ethyl)-2,5-dihydro-pyrazolo[4,3-c]pyridin-4-one | CHEMBL14996 |
Type | Small organic molecule |
Emp. Form. | C8H10N4O3 |
Mol. Mass. | 210.19 |
SMILES | Nc1n(CCO)[nH]c2cc(=O)[nH]c(=O)c12 |
Structure |
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