| Reaction Details |
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 | Report a problem with these data |
| Target | Queuine tRNA-ribosyltransferase |
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| Ligand | BDBM50125769 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_225394 (CHEMBL847432) |
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| Ki | 100±n/a nM |
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| Citation |  Brenk, R; Naerum, L; Grädler, U; Gerber, HD; Garcia, GA; Reuter, K; Stubbs, MT; Klebe, G Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis. J Med Chem46:1133-43 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Queuine tRNA-ribosyltransferase |
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| Name: | Queuine tRNA-ribosyltransferase |
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| Synonyms: | TGT_ZYMMO | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase (TGT) | tgt |
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| Type: | Protein |
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| Mol. Mass.: | 42844.19 |
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| Organism: | Zymomonas mobilis |
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| Description: | P28720 |
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| Residue: | 386 |
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| Sequence: | MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEE
GVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAK
RSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEM
FRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPI
NIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQK
IRDSISEGRFSQFAQDFRARYFARNS
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| BDBM50125769 |
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| n/a |
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| Name | BDBM50125769 |
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| Synonyms: | 2,6-Diamino-8-phenylsulfanylmethyl-3H-quinazolin-4-one | CHEMBL14926 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N4OS |
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| Mol. Mass. | 298.363 |
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| SMILES | Nc1cc(CSc2ccccc2)c2nc(N)[nH]c(=O)c2c1 |
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| Structure | 
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