| Reaction Details |
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 | Report a problem with these data |
| Target | Progesterone receptor |
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| Ligand | BDBM50126158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_177403 (CHEMBL782725) |
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| IC50 | 7.43±n/a nM |
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| Citation |  Fensome, A; Koko, M; Wrobel, J; Zhang, P; Zhang, Z; Cohen, J; Lundeen, S; Rudnick, K; Zhu, Y; Winneker, R Novel 5-aryl-1,3-dihydro-indole-2-thiones. potent, orally active progesterone receptor agonists. Bioorg Med Chem Lett13:1317-20 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Progesterone receptor |
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| Name: | Progesterone receptor |
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| Synonyms: | Nr3c3 | Nuclear receptor subfamily 3 group C member 3 | PR | PRGR_RAT | Pgr | Progesterone Receptor (PR) | Progesterone receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99414.34 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_159714 |
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| Residue: | 923 |
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| Sequence: | MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSDASSVVSPIPISLDRLL
FSRSCQAQELPDEKTQNQQSLSDVEGAFSGVEASRRRSRNPRAPEKDSRLLDSVLDTLLA
PSGPEQSQTSPPACEAITSWCLFGPELPEDPRSVPATKGLLSPLMSRPESKAGDSSGTGA
GQKVLPKAVSPPRQLLLPTSGSAHWPGAGVKPSQQPATVEVEEDGGLETEGSAGPLLKSK
PRALEGMCSGGGVTANAPGAAPGGVTLVPKEDSRFSAPRVSLEQDAPVAPGRSPLATTVV
DFIHVPILPLNHALLAARTRQLLEGDSYDGGAAAQVPFAPPRGSPSAPSPPVPCGDFPDC
TYPPEGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPP
RPPRAPPSRPGEAAVAAPSAAVSPVSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAAS
SCLLPRDSLPAAPTSSAAPAIYPPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSE
ASQSPQYGFDSLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCI
VDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDGVALPQSVAFPNESQTLG
QRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVV
KWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMK
ELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIR
ELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMS
EVIAAQLPKILAGMVKPLLFHKK
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| BDBM50126158 |
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| n/a |
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| Name | BDBM50126158 |
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| Synonyms: | 3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-5'-yl)benzonitrile | CHEMBL28157 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17FN2S |
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| Mol. Mass. | 336.426 |
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| SMILES | Fc1cc(cc(c1)-c1ccc2NC(=S)C3(CCCCC3)c2c1)C#N |
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| Structure | 
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