| Reaction Details |
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 | Report a problem with these data |
| Target | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Ligand | BDBM16181 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_38702 (CHEMBL651598) |
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| EC50 | 4±n/a nM |
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| Citation |  Gwaltney, SL; O'Connor, SJ; Nelson, LT; Sullivan, GM; Imade, H; Wang, W; Hasvold, L; Li, Q; Cohen, J; Gu, WZ; Tahir, SK; Bauch, J; Marsh, K; Ng, SC; Frost, DJ; Zhang, H; Muchmore, S; Jakob, CG; Stoll, V; Hutchins, C; Rosenberg, SH; Sham, HL Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency. Bioorg Med Chem Lett13:1363-6 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Name: | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Synonyms: | Protein farnesyltransferase | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 38702 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
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| Synonyms: | CAAX farnesyltransferase subunit alpha | FNTA_MOUSE | FTase-alpha | Fnta | GGTase-I-alpha | Geranylgeranyl transferase type 1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43994.09 |
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| Organism: | Mus musculus |
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| Description: | EBI_10570 |
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| Residue: | 377 |
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| Sequence: | MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDS
PTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLK
DPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQR
HFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLL
DLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHCRESDIPASV
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| Component 2 |
| Name: | Protein farnesyltransferase subunit beta |
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| Synonyms: | FNTB_MOUSE | Fntb | Protein farnesyltransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48811.61 |
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| Organism: | Mus musculus |
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| Description: | EBI_12341 |
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| Residue: | 437 |
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| Sequence: | MASSSSFTYYCPPSSSPVWSEPLYSLRPEHVRERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLILQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPV
PGFEECEDEVTSDPATD
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| BDBM16181 |
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| n/a |
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| Name | BDBM16181 |
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| Synonyms: | 1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethyl]-5-(naphthalen-1-yl)-1,2,3,6-tetrahydropyridine-4-carbonitrile | 1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydropyridine-4-carbonitrile | A345677 | CHEMBL282161 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25N5O |
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| Mol. Mass. | 459.5417 |
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| SMILES | Cn1cncc1C(O)(CN1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:15| |
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| Structure | 
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