| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor 1 |
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| Ligand | BDBM50126763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_90138 (CHEMBL884410) |
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| EC50 | 22000±n/a nM |
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| Citation |  Brehm, L; Greenwood, JR; Hansen, KB; Nielsen, B; Egebjerg, J; Stensbøl, TB; Bräuner-Osborne, H; Sløk, FA; Kronborg, TT; Krogsgaard-Larsen, P (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology. J Med Chem46:1350-8 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor 1 |
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| Name: | Glutamate receptor 1 |
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| Synonyms: | AMPA-selective glutamate receptor 1 | GLUH1 | GLUR1 | GRIA1 | GRIA1_HUMAN | GluR-1 | GluR-A | GluR-K1 | Glutamate AMPA 1 | Glutamate receptor 1 | Glutamate receptor AMPA 1/2 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 101512.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glutamate AMPA 1 GRIA1 HUMAN::P42261 |
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| Residue: | 906 |
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| Sequence: | MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKW
WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMP
LGATGL
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| BDBM50126763 |
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| n/a |
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| Name | BDBM50126763 |
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| Synonyms: | (S)-2-amino-3-(3-hydroxy-5-tert-butyl-4-isoxazolyl)propionic acid | 2-Amino-3-(5-tert-butyl-3-hydroxy-isoxazol-4-yl)-propionic acid | CHEMBL27130 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H16N2O4 |
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| Mol. Mass. | 228.245 |
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| SMILES | CC(C)(C)c1o[nH]c(=O)c1C[C@H](N)C(O)=O |
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| Structure | 
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