Reaction Details |
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Target | Aldo-keto reductase family 1 member A1 |
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Ligand | BDBM50126791 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_31327 (CHEMBL644880) |
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IC50 | 3570±n/a nM |
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Citation | Da Settimo, F; Primofiore, G; Da Settimo, A; La Motta, C; Simorini, F; Novellino, E; Greco, G; Lavecchia, A; Boldrini, E Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives. J Med Chem46:1419-28 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member A1 |
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Name: | Aldo-keto reductase family 1 member A1 |
Synonyms: | AK1A1_RAT | Akr1a1 | Aldehyde reductase | Alr |
Type: | PROTEIN |
Mol. Mass.: | 36509.97 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_31321 |
Residue: | 325 |
Sequence: | MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGEAL
KESVGAGKAVPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK
HGRSPAQILLRWQVQRKVICIPKSITPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV
PMITVDGKRVPRDAGHPLYPFNDPY
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BDBM50126791 |
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n/a |
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Name | BDBM50126791 |
Synonyms: | CHEMBL281442 | Cyano-[1-(4-methyl-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C19H16N2O3 |
Mol. Mass. | 320.3419 |
SMILES | Cc1ccc(CN2C(=O)C(C(C#N)C(O)=O)c3ccccc23)cc1 |
Structure |
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