| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Methionine synthase |
|---|
| Ligand | BDBM50564145 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2086768 (CHEMBL4768031) |
|---|
| IC50 | 12100±n/a nM |
|---|
| Citation |  Wang, M; Tian, C; Xue, L; Li, H; Cong, J; Fang, F; Yang, J; Yuan, M; Chen, Y; Guo, Y; Wang, X; Liu, J; Zhang, Z Design, synthesis and biological activity of N Eur J Med Chem190:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Methionine synthase |
|---|
| Name: | Methionine synthase |
|---|
| Synonyms: | 5-methyltetrahydrofolate--homocysteine methyltransferase | METH_HUMAN | MS | MTR | Vitamin-B12 dependent methionine synthase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 140503.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_854111 |
|---|
| Residue: | 1265 |
|---|
| Sequence: | MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHA
RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC
SAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA
KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQT
GEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDET
PSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL
EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDG
MLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD
FLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNI
LTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLY
HAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKV
IQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVG
DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATV
KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM
IFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN
LKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQV
FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTL
ISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYY
CLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEE
LHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTG
IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPIL
GYDTD
|
|
|
|---|
| BDBM50564145 |
|---|
| n/a |
|---|
| Name | BDBM50564145 |
|---|
| Synonyms: | CHEMBL4778495 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H24ClN5O |
|---|
| Mol. Mass. | 373.88 |
|---|
| SMILES | CCc1ccc(CCC2CCc3nc(N)nc(N)c3N2C(=O)CCl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
