Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM31093 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2086788 (CHEMBL4768051) |
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IC50 | 172±n/a nM |
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Citation | Fan, C; Zhong, T; Yang, H; Yang, Y; Wang, D; Yang, X; Xu, Y; Fan, Y Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition. Eur J Med Chem190:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AURKB_MOUSE | Aik2 | Aim1 | Airk2 | Ark2 | Aurkb | Serine/threonine-protein kinase 12 | Stk1 | Stk12 | Stk5 |
Type: | PROTEIN |
Mol. Mass.: | 39401.97 |
Organism: | Mus musculus |
Description: | ChEMBL_1339463 |
Residue: | 345 |
Sequence: | MAQKENAYPWPYGSKTSQSGLNTLSQRVLRKEPATTSALALVNRFNSQSTAAPGQKLAEN
KSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEK
EGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDEQ
RTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCG
TLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVDLKFPSS
VPSGAQDLISKLLKHNPWQRLPLAEVAAHPWVRANSRRVLPPSAL
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BDBM31093 |
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n/a |
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Name | BDBM31093 |
Synonyms: | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | BDBM31832 | CHEMBL259084 | MLN-8054 | cid_11712649 |
Type | Small organic molecule |
Emp. Form. | C25H15ClF2N4O2 |
Mol. Mass. | 476.862 |
SMILES | OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 |c:13| |
Structure |
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