Reaction Details |
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Target | Prostaglandin D2 receptor |
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Ligand | BDBM50128726 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_157790 (CHEMBL878773) |
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IC50 | 720±n/a nM |
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Citation | Mitsumori, S; Tsuri, T; Honma, T; Hiramatsu, Y; Okada, T; Hashizume, H; Inagaki, M; Arimura, A; Yasui, K; Asanuma, F; Kishino, J; Ohtani, M Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives. J Med Chem46:2436-45 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin D2 receptor |
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Name: | Prostaglandin D2 receptor |
Synonyms: | PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor |
Type: | Enzyme |
Mol. Mass.: | 40288.87 |
Organism: | Homo sapiens (Human) |
Description: | Q13258 |
Residue: | 359 |
Sequence: | MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV
FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST
LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG
TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT
RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS
EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
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BDBM50128726 |
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n/a |
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Name | BDBM50128726 |
Synonyms: | (+) 7-[3-(4-tert-Butyl-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid | CHEMBL309847 |
Type | Small organic molecule |
Emp. Form. | C24H35NO4S |
Mol. Mass. | 433.604 |
SMILES | CC(C)(C)c1ccc(cc1)S(=O)(=O)N[C@@H]1[C@@H]2CC[C@@H](C2)[C@H]1C\C=C/CCCC(O)=O |
Structure |
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