Reaction Details |
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Target | Calcium-activated potassium channel subunit alpha-1 |
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Ligand | BDBM50128981 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_39096 |
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EC50 | 17000±n/a nM |
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Citation | Turner, SC; Carroll, WA; White, TK; Gopalakrishnan, M; Coghlan, MJ; Shieh, CC; Zhang, XF; Parihar, AS; Buckner, SA; Milicic, I; Sullivan, JP The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles. Bioorg Med Chem Lett13:2003-7 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Calcium-activated potassium channel subunit alpha-1 |
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Name: | Calcium-activated potassium channel subunit alpha-1 |
Synonyms: | Calcium-activated potassium channel alpha/beta 1 | KCMA1_HUMAN | KCNMA | KCNMA1 | Large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b | SLO |
Type: | PROTEIN |
Mol. Mass.: | 137567.62 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_938830 |
Residue: | 1236 |
Sequence: | MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS
VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH
CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL
WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL
VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES
VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK
IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW
NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE
MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG
FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERD
CSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPN
TSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSG
HVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVS
ILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIG
VLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDD
DPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEEN
ALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRL
RDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSS
KKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
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BDBM50128981 |
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n/a |
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Name | BDBM50128981 |
Synonyms: | 1-(3-Cyano-1H-pyrrolo[3,2-b]pyridin-2-yl)-piperidine-4-carboxylic acid methyl ester | CHEMBL303577 |
Type | Small organic molecule |
Emp. Form. | C15H16N4O2 |
Mol. Mass. | 284.3131 |
SMILES | COC(=O)C1CCN(CC1)c1[nH]c2cccnc2c1C#N |
Structure |
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