| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium-activated potassium channel subunit alpha-1 |
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| Ligand | BDBM50128984 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_39096 |
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| EC50 | 6750±n/a nM |
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| Citation |  Turner, SC; Carroll, WA; White, TK; Gopalakrishnan, M; Coghlan, MJ; Shieh, CC; Zhang, XF; Parihar, AS; Buckner, SA; Milicic, I; Sullivan, JP The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles. Bioorg Med Chem Lett13:2003-7 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium-activated potassium channel subunit alpha-1 |
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| Name: | Calcium-activated potassium channel subunit alpha-1 |
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| Synonyms: | Calcium-activated potassium channel alpha/beta 1 | KCMA1_HUMAN | KCNMA | KCNMA1 | Large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b | SLO |
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| Type: | PROTEIN |
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| Mol. Mass.: | 137567.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_938830 |
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| Residue: | 1236 |
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| Sequence: | MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS
VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH
CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL
WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL
VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES
VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK
IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW
NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE
MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG
FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERD
CSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPN
TSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSG
HVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVS
ILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIG
VLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDD
DPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEEN
ALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRL
RDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSS
KKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
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| BDBM50128984 |
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| n/a |
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| Name | BDBM50128984 |
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| Synonyms: | 2-[(2-Dimethylamino-ethyl)-methyl-amino]-1H-pyrrolo[3,2-b]pyridine-3-carbonitrile | CHEMBL303736 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17N5 |
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| Mol. Mass. | 243.3076 |
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| SMILES | CN(C)CCN(C)c1[nH]c2cccnc2c1C#N |
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| Structure | 
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