| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine--tRNA ligase, cytoplasmic |
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| Ligand | BDBM50129536 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105278 (CHEMBL718946) |
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| IC50 | 8990±n/a nM |
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| Citation |  Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors. Bioorg Med Chem Lett13:2231-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine--tRNA ligase, cytoplasmic |
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| Name: | Methionine--tRNA ligase, cytoplasmic |
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| Synonyms: | MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 101110.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105283 |
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| Residue: | 900 |
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| Sequence: | MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
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| BDBM50129536 |
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| n/a |
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| Name | BDBM50129536 |
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| Synonyms: | 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid | CHEMBL70567 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H12Cl4N2O2 |
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| Mol. Mass. | 478.155 |
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| SMILES | OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccc(Cl)cc1Cl |
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| Structure | 
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