| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Methionine--tRNA ligase, cytoplasmic |
|---|
| Ligand | BDBM50129538 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_105286 (CHEMBL718953) |
|---|
| IC50 | 20900±n/a nM |
|---|
| Citation |  Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors. Bioorg Med Chem Lett13:2231-4 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Methionine--tRNA ligase, cytoplasmic |
|---|
| Name: | Methionine--tRNA ligase, cytoplasmic |
|---|
| Synonyms: | MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 101110.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_105283 |
|---|
| Residue: | 900 |
|---|
| Sequence: | MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
|
|
|
|---|
| BDBM50129538 |
|---|
| n/a |
|---|
| Name | BDBM50129538 |
|---|
| Synonyms: | 5-(3'-Chloro-4'-fluoro-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid | CHEMBL70536 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H12Cl3FN2O2 |
|---|
| Mol. Mass. | 461.7 |
|---|
| SMILES | OC(=O)c1cc(-c2ccc(cc2)-c2ccc(F)c(Cl)c2)n(n1)-c1ccc(Cl)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
