Reaction Details |
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Target | Methionine--tRNA ligase, cytoplasmic |
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Ligand | BDBM50129544 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_105283 |
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IC50 | 1510±n/a nM |
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Citation | Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors. Bioorg Med Chem Lett13:2231-4 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Methionine--tRNA ligase, cytoplasmic |
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Name: | Methionine--tRNA ligase, cytoplasmic |
Synonyms: | MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 101110.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105283 |
Residue: | 900 |
Sequence: | MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
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BDBM50129544 |
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n/a |
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Name | BDBM50129544 |
Synonyms: | 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid | CHEMBL307466 |
Type | Small organic molecule |
Emp. Form. | C23H16Cl2N2O3 |
Mol. Mass. | 439.291 |
SMILES | COc1ccccc1-n1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O |
Structure |
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