| Reaction Details |
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 | Report a problem with these data |
| Target | Gap junction beta-2 protein |
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| Ligand | BDBM50565237 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2091062 (CHEMBL4772325) |
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| IC50 | 17200±n/a nM |
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| Citation |  Subedi, YP; Kjellgren, A; Roberts, P; Montgomery, H; Thackeray, N; Fiori, MC; Altenberg, GA; Chang, CT Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels. Eur J Med Chem203:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gap junction beta-2 protein |
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| Name: | Gap junction beta-2 protein |
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| Synonyms: | CXB2_HUMAN | Connexin-26 | Cx26 | GJB2 | Gap junction beta-2 protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26226.37 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117983 |
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| Residue: | 226 |
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| Sequence: | MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGC
KNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEE
IKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDC
FVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV
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| BDBM50565237 |
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| n/a |
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| Name | BDBM50565237 |
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| Synonyms: | CHEMBL4776897 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H39ClN4O11 |
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| Mol. Mass. | 595.04 |
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| SMILES | [H][C@]1(O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@@]3([H])O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)O[C@H](COc2ccc(Cl)cc2)[C@@H](O)[C@H](N)[C@H]1O |r| |
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| Structure | 
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