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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 4 | ||
| Ligand | BDBM50129898 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_53208 (CHEMBL664029) | ||
| IC50 | 10±n/a nM | ||
| Citation |  Villhauer, EB; Brinkman, JA; Naderi, GB; Burkey, BF; Dunning, BE; Prasad, K; Mangold, BL; Russell, ME; Hughes, TE 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem46:2774-89 (2003) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 4 | |||
| Name: | Dipeptidyl peptidase 4 | ||
| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 88271.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27487 | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM50129898 | |||
| n/a | |||
| Name | BDBM50129898 | ||
| Synonyms: | 1-{2-[4-(Benzothiazol-2-ylamino)-cyclohexylamino]-acetyl}-pyrrolidine-2-carbonitrile | CHEMBL92075 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H25N5OS | ||
| Mol. Mass. | 383.51 | ||
| SMILES | O=C(CNC1CC[C@@H](CC1)Nc1nc2ccccc2s1)N1CCC[C@H]1C#N |wD:24.28,7.10,(.52,3.61,;.85,2.1,;-.3,1.07,;-1.77,1.53,;-2.91,.49,;-2.91,-1.05,;-4.24,-1.8,;-5.55,-1.05,;-5.55,.49,;-4.24,1.28,;-6.9,-1.8,;-6.91,-3.34,;-8.16,-4.25,;-7.69,-5.72,;-8.46,-7.03,;-7.69,-8.38,;-6.15,-8.36,;-5.38,-7.05,;-6.15,-5.72,;-5.66,-4.25,;2.32,1.63,;2.8,.16,;4.35,.16,;4.83,1.63,;3.57,2.54,;4.32,3.89,;5.09,5.22,)| | ||
| Structure | 
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