Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50130312 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_216593 (CHEMBL821384) |
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Ki | 0.018±n/a nM |
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Citation | Pineda, P; Kanter, A; McIvor, RS; Benkovic, SJ; Rosowsky, A; Wagner, CR Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate. J Med Chem46:2816-8 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_MOUSE | Dhfr |
Type: | Enzyme |
Mol. Mass.: | 21608.82 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50130312 |
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n/a |
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Name | BDBM50130312 |
Synonyms: | 4-[12-(4-Carboxy-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-dodecylcarbamoyl]-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid | CHEMBL406356 |
Type | Small organic molecule |
Emp. Form. | C52H68N18O8 |
Mol. Mass. | 1073.2121 |
SMILES | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(=O)NCCCCCCCCCCCCNC(=O)CCC(NC(=O)c1ccc(cc1)N(C)Cc1cnc2nc(N)nc(N)c2n1)C(O)=O)C(O)=O |
Structure |
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