Reaction Details |
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Target | Tumor necrosis factor |
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Ligand | BDBM50566080 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2094429 (CHEMBL4775692) |
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IC50 | 7960±n/a nM |
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Citation | Dietrich, JD; Longenecker, KL; Wilson, NS; Goess, C; Panchal, SC; Swann, SL; Petros, AM; Hobson, AD; Ihle, D; Song, D; Richardson, P; Comess, KM; Cox, PB; Dombrowski, A; Sarris, K; Donnelly-Roberts, DL; Duignan, DB; Gomtsyan, A; Jung, P; Krueger, AC; Mathieu, S; McClure, A; Stoll, VS; Wetter, J; Mankovich, JA; Hajduk, PJ; Vasudevan, A; Stoffel, RH; Sun, C Development of Orally Efficacious Allosteric Inhibitors of TNF? via Fragment-Based Drug Design. J Med Chem64:417-429 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tumor necrosis factor |
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Name: | Tumor necrosis factor |
Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
Type: | Enzyme |
Mol. Mass.: | 25645.11 |
Organism: | Homo sapiens (Human) |
Description: | P01375 |
Residue: | 233 |
Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM50566080 |
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n/a |
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Name | BDBM50566080 |
Synonyms: | CHEMBL4783333 |
Type | Small organic molecule |
Emp. Form. | C17H12N2 |
Mol. Mass. | 244.2906 |
SMILES | N#CCc1ccc(cc1)-c1cccc2ccncc12 |
Structure |
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