| Reaction Details |
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 | Report a problem with these data |
| Target | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Ligand | BDBM50566439 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2100455 (CHEMBL4808851) |
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| IC50 | >10000±n/a nM |
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| Citation |  Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity. J Med Chem64:4462-4477 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Name: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE6C | PDE6C_HUMAN | PDEA2 | Phosphodiesterase 6C | Phosphodiesterase 6C (PDE6C) |
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| Type: | Protein |
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| Mol. Mass.: | 99132.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51160 |
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| Residue: | 858 |
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| Sequence: | MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML
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| BDBM50566439 |
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| n/a |
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| Name | BDBM50566439 |
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| Synonyms: | CHEMBL4869439 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31FN4O2 |
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| Mol. Mass. | 486.5804 |
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| SMILES | COc1ccc(cc1F)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)c1ccccc1C |c:12| |
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| Structure | 
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