| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide N-methyltransferase |
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| Ligand | BDBM50566779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2101684 (CHEMBL4810080) |
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| IC50 | 263±n/a nM |
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| Citation |  Hayashi, K; Uehara, S; Yamamoto, S; Cary, DR; Nishikawa, J; Ueda, T; Ozasa, H; Mihara, K; Yoshimura, N; Kawai, T; Ono, T; Yamamoto, S; Fumoto, M; Mikamiyama, H Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. ACS Med Chem Lett12:1093-1101 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide N-methyltransferase |
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| Name: | Nicotinamide N-methyltransferase |
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| Synonyms: | 2.1.1.1 | NNMT_MOUSE | Nicotinamide N-methyltransferase | Nnmt |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29592.91 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117911 |
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| Residue: | 264 |
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| Sequence: | MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLI
DIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGN
RMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSLPPADCLLSTLCLDAACPDLPAYRTAL
RNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQ
NYSSTTSNNEGLFSLVGRKPGRSE
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| BDBM50566779 |
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| n/a |
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| Name | BDBM50566779 |
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| Synonyms: | CHEMBL4878905 |
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| Type | Small organic molecule |
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| Emp. Form. | C57H72F3N11O10S |
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| Mol. Mass. | 1160.309 |
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| SMILES | CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CSC[C@H](NC(=O)[C@H](Cc2ccc(cc2)C(N)=O)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](CCCCN)NC1=O)C(F)(F)F)C(N)=O |r| |
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| Structure | 
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