| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50567007 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2102220 (CHEMBL4810616) |
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| IC50 | 70±n/a nM |
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| Citation |  Kozlova, A; Thabault, L; Liberelle, M; Klaessens, S; Prévost, JRC; Mathieu, C; Pilotte, L; Stroobant, V; Van den Eynde, B; Frédérick, R Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase. J Med Chem64:10967-10980 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47874.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_825691 |
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| Residue: | 406 |
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| Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
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| BDBM50567007 |
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| n/a |
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| Name | BDBM50567007 |
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| Synonyms: | CHEMBL4852583 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12N2 |
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| Mol. Mass. | 244.2906 |
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| SMILES | c1[nH]c2ccccc2c1-c1ccc2ccncc2c1 |
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| Structure | 
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