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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prostaglandin G/H synthase 2 | ||
| Ligand | BDBM50131608 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_159893 (CHEMBL766721) | ||
| IC50 | 6±n/a nM | ||
| Citation |  Almansa, C; Alfón, J; de Arriba, AF; Cavalcanti, FL; Escamilla, I; Gómez, LA; Miralles, A; Soliva, R; Bartrolí, J; Carceller, E; Merlos, M; García-Rafanell, J Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles. J Med Chem46:3463-75 (2003) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prostaglandin G/H synthase 2 | |||
| Name: | Prostaglandin G/H synthase 2 | ||
| Synonyms: | COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 69003.89 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI). | ||
| Residue: | 604 | ||
| Sequence: |
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| BDBM50131608 | |||
| n/a | |||
| Name | BDBM50131608 | ||
| Synonyms: | 4-Chloro-5-(2,3-dichloro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-imidazole | CHEMBL324826 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H11Cl3N2O2S | ||
| Mol. Mass. | 401.695 | ||
| SMILES | CS(=O)(=O)c1ccc(cc1)-n1cnc(Cl)c1-c1cccc(Cl)c1Cl |(14.99,-4.85,;13.47,-5.19,;13.82,-6.69,;13.14,-3.68,;11.97,-5.52,;10.92,-4.4,;9.42,-4.75,;8.96,-6.22,;10.01,-7.35,;11.51,-7.01,;7.46,-6.57,;6.93,-8,;5.41,-7.93,;4.99,-6.46,;3.65,-5.69,;6.27,-5.61,;6.27,-4.05,;4.94,-3.28,;4.94,-1.74,;6.27,-.97,;7.6,-1.74,;8.94,-.96,;7.6,-3.28,;8.94,-4.07,)| | ||
| Structure | 
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