| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
|---|
| Ligand | BDBM50131659 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_58964 (CHEMBL669521) |
|---|
| IC50 | 40.5±n/a nM |
|---|
| Citation |  Meltzer, PC; Blundell, P; Zona, T; Yang, L; Huang, H; Bonab, AA; Livni, E; Fischman, A; Madras, BK A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain. J Med Chem46:3483-96 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent dopamine transporter |
|---|
| Name: | Sodium-dependent dopamine transporter |
|---|
| Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 68497.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q01959 |
|---|
| Residue: | 620 |
|---|
| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
|
|
|
|---|
| BDBM50131659 |
|---|
| n/a |
|---|
| Name | BDBM50131659 |
|---|
| Synonyms: | 2beta-carboxylic acid methoxymethylamide-3beta-(4-fluorophenyl)-8-methyl-8-azabicyclo [3.2.1] octane | CHEMBL119728 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H36FN4O4ReS2 |
|---|
| Mol. Mass. | 725.913 |
|---|
| SMILES | CON(C)C(=O)C1C2CCC(CC1c1ccc(F)cc1)N2CCCN1CCS[Re]2(=O)SCCN2C(=O)C1 |TLB:21:20:6.12.11:8.9,THB:13:12:20:8.9,4:6:20:8.9| |
|---|
| Structure | 
|
|---|
Search and Browse
