| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50131653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_58964 (CHEMBL669521) |
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| IC50 | 1.50±n/a nM |
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| Citation |  Meltzer, PC; Blundell, P; Zona, T; Yang, L; Huang, H; Bonab, AA; Livni, E; Fischman, A; Madras, BK A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain. J Med Chem46:3483-96 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68497.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q01959 |
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| Residue: | 620 |
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| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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| BDBM50131653 |
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| n/a |
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| Name | BDBM50131653 |
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| Synonyms: | (1R,12R) -N-[ (2- ( ( 3'-N-propyl-3''alpha- (4-fluorophenyl) tropane-2''beta-propionyl) (2-mercaptoethyl) amino) acetyl) -2-aminoethanethiolato] rhenium(v) oxide | (1R,12S) -N-[ (2- ( (3'-N-propyl-3''alpha-( 4-fluorophenyl) tropane-2''beta-propionyl) (2-mercaptoethyl) amino) -2-aminoethanethiolato]rhenium(v) oxide | CHEMBL326165 | N-[ (2- ( (3'-N-propyl- (1'' R) -3''alpha-(4-fluorophenyl) tropane-2''beta-1-propanoyl) (2-mercaptoethyl) amino) acetyl) -2-aminoethanethiolato] rhenium (V) oxide | N-[ (2-( ( 3'-N-propyl-( 1''R) -3''beta-(4-fluorophenyl) tropane-2''-beta-1-propanoyl) (2-mercaptoethyl) amino) acetyl) -2-aminoethanethiolato)rhenium(V) oxide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H35FN3O3ReS2 |
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| Mol. Mass. | 694.899 |
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| SMILES | CCC(=O)C1C2CCC(CC1c1ccc(F)cc1)N2CCCN1CCS[Re]2(=O)SCCN2C(=O)C1 |TLB:19:18:4.10.9:6.7,THB:11:10:18:6.7,2:4:18:6.7| |
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| Structure | 
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