Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM422122

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2102445 (CHEMBL4810841)

EC50

0.002000±n/a nM

Citation

Tora, G; Jiang, J; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; Xu, C; Galella, MA; Wang, T; He, Y; Wexler, RR; Finlay, HJ Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists. Bioorg Med Chem Lett50:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM422122

n/a

Name

BDBM422122

Synonyms:

2-butyl-1-(2,6- dimethoxyphenyl)-5-[4- (6-fluoropyridin-3- yl)benzenesulfonyl]-6- hydroxy-1,4- dihydropyrimidin-4-one | US10508104, Example 15

Type

Small organic molecule

Emp. Form.

C27H26FN3O6S

Mol. Mass.

539.575

SMILES

CCCCc1nc(=O)c(c(O)n1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1 |(-9.34,.77,;-8,,;-6.67,.77,;-5.33,,;-4,.77,;-4,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,2.31,;-1.33,.77,;;-2.67,,;-2.67,-1.54,;-4,-2.31,;-5.33,-1.54,;-6.67,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;,3.08,;-.77,4.41,;.77,4.41,;1.33,2.31,;1.33,.77,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;5.33,,;5.33,-1.54,;6.67,-2.31,;8,-1.54,;9.34,-2.31,;8,,;6.67,.77,)|

Structure