Reaction Details |
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Target | Aldehyde dehydrogenase family 1 member A3 |
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Ligand | BDBM50567353 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2103063 (CHEMBL4811566) |
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IC50 | 600±n/a nM |
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Citation | Huddle, BC; Grimley, E; Chtcherbinine, M; Buchman, CD; Takahashi, C; Debnath, B; McGonigal, SC; Mao, S; Li, S; Felton, J; Pan, S; Wen, B; Sun, D; Neamati, N; Buckanovich, RJ; Hurley, TD; Larsen, SD Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy. Eur J Med Chem211:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldehyde dehydrogenase family 1 member A3 |
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Name: | Aldehyde dehydrogenase family 1 member A3 |
Synonyms: | AL1A3_HUMAN | ALDH1A3 | ALDH6 | Aldehyde dehydrogenase 6 | Aldehyde dehydrogenase family 1 member A3 | RALDH-3 | RalDH3 | Retinaldehyde dehydrogenase 3 |
Type: | PROTEIN |
Mol. Mass.: | 56110.85 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109700 |
Residue: | 512 |
Sequence: | MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
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BDBM50567353 |
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n/a |
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Name | BDBM50567353 |
Synonyms: | CHEMBL4865571 |
Type | Small organic molecule |
Emp. Form. | C20H16FN3OS |
Mol. Mass. | 365.424 |
SMILES | Cn1ccc2c1nc(SCc1cccc(F)c1)n(-c1ccccc1)c2=O |
Structure |
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