| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-C |
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| Ligand | BDBM50567848 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2103907 (CHEMBL4812410) |
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| Ki | 8.0±n/a nM |
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| Citation |  Yu, M; Long, Y; Yang, Y; Li, M; Teo, T; Noll, B; Philip, S; Wang, S Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation. Eur J Med Chem218:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-C |
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| Name: | Cyclin-C |
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| Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33244.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107900 |
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| Residue: | 283 |
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| Sequence: | MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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| BDBM50567848 |
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| n/a |
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| Name | BDBM50567848 |
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| Synonyms: | CHEMBL4847659 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20ClN3OS |
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| Mol. Mass. | 361.889 |
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| SMILES | Cc1ccsc1-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1 |
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| Structure | 
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