| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine kinase |
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| Ligand | BDBM50132280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_31131 (CHEMBL643559) |
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| IC50 | 2.8±n/a nM |
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| Citation |  Zheng, GZ; Mao, Y; Lee, CH; Pratt, JK; Koenig, JR; Perner, RJ; Cowart, MD; Gfesser, GA; McGaraughty, S; Chu, KL; Zhu, C; Yu, H; Kohlhaas, K; Alexander, KM; Wismer, CT; Mikusa, J; Jarvis, MF; Kowaluk, EA; Stewart, AO Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity. Bioorg Med Chem Lett13:3041-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine kinase |
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| Name: | Adenosine kinase |
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| Synonyms: | ADK | ADK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40545.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1467841 |
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| Residue: | 362 |
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| Sequence: | MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH
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| BDBM50132280 |
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| n/a |
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| Name | BDBM50132280 |
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| Synonyms: | 5-(3-Bromo-phenyl)-7-{6-[4-(tetrahydro-pyran-4-yloxymethyl)-piperidin-1-yl]-pyridazin-3-yl}-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL101805 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30BrN7O2 |
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| Mol. Mass. | 576.488 |
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| SMILES | Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nn1)N1CCC(COC2CCOCC2)CC1 |
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| Structure | 
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