| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine kinase |
|---|
| Ligand | BDBM50132279 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_31131 (CHEMBL643559) |
|---|
| IC50 | 7.2±n/a nM |
|---|
| Citation |  Zheng, GZ; Mao, Y; Lee, CH; Pratt, JK; Koenig, JR; Perner, RJ; Cowart, MD; Gfesser, GA; McGaraughty, S; Chu, KL; Zhu, C; Yu, H; Kohlhaas, K; Alexander, KM; Wismer, CT; Mikusa, J; Jarvis, MF; Kowaluk, EA; Stewart, AO Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity. Bioorg Med Chem Lett13:3041-4 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine kinase |
|---|
| Name: | Adenosine kinase |
|---|
| Synonyms: | ADK | ADK_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40545.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1467841 |
|---|
| Residue: | 362 |
|---|
| Sequence: | MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH
|
|
|
|---|
| BDBM50132279 |
|---|
| n/a |
|---|
| Name | BDBM50132279 |
|---|
| Synonyms: | 5-(3-Bromo-phenyl)-7-[6-(3,4-diethoxy-pyrrolidin-1-yl)-pyridazin-3-yl]-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL102989 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H26BrN7O2 |
|---|
| Mol. Mass. | 536.424 |
|---|
| SMILES | CCO[C@@H]1CN(C[C@@H]1OCC)c1ccc(nn1)-c1cc(-c2cccc(Br)c2)c2c(N)ncnc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
