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TargetMitogen-activated protein kinase 14
LigandBDBM14831
Substrate/Competitorn/a
Meas. Tech.ChEMBL_124492 (CHEMBL733328)
Kd 1190±n/a nM
Citation Regan, J; Pargellis, CA; Cirillo, PF; Gilmore, T; Hickey, ER; Peet, GW; Proto, A; Swinamer, A; Moss, N The kinetics of binding to p38MAP kinase by analogues of BIRB 796. Bioorg Med Chem Lett13:3101-4 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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  Blast E-value cutoff:
BDBM14831
n/a
NameBDBM14831
Synonyms:3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chlorophenyl)urea | 3-(4-chlorophenyl)-1-(2-methyl-5-tert-butyl-pyrazol-3-yl)urea | CHEMBL87277 | Dopamine D2 receptor and serotonin 2a receptor | diaryl urea compound 2 | diaryl urea inhibitor 1
TypeSmall organic molecule
Emp. Form.C15H19ClN4O
Mol. Mass.306.791
SMILESCn1nc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C
Structure
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