| Reaction Details |
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 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
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| Ligand | BDBM50568144 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2104739 (CHEMBL4813242) |
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| IC50 | 39±n/a nM |
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| Citation |  Vanjare, BD; Choi, NG; Mahajan, PG; Raza, H; Hassan, M; Han, Y; Yu, SM; Kim, SJ; Seo, SY; Lee, KH Novel 1,3,4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies. Bioorg Med Chem41:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyphenol oxidase 2 |
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| Name: | Polyphenol oxidase 2 |
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| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
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| Type: | Protein |
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| Mol. Mass.: | 63923.66 |
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| Organism: | Agaricus bisporus (Common mushroom) |
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| Description: | O42713 |
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| Residue: | 556 |
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| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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| BDBM50568144 |
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| n/a |
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| Name | BDBM50568144 |
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| Synonyms: | CHEMBL4867234 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12BrN3O2S |
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| Mol. Mass. | 390.254 |
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| SMILES | Brc1ccc(NC(=O)CSc2nnc(o2)-c2ccccc2)cc1 |
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| Structure | 
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