Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetNR2B Channel Blocker
LigandBDBM50133126
Substrate/Competitorn/a
Meas. Tech.ChEMBL_196897
Ki 1.9±n/a nM
Citation Michellys PYArdecky RJChen JHD'Arrigo JGrese TAKaranewsky DSLeibowitz MDLiu SMais DAMapes CMMontrose-Rafizadeh COgilvie KMReifel-Miller ARungta DThompson AWTyhonas JSBoehm MF Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. J Med Chem 46:4087-103 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NR2B Channel Blocker
Name:Retinoid X receptor alpha
Synonyms:Retinoic acid receptor RXR-alpha
Type:Enzyme Catalytic Domain
Mol. Mass.:51273.78
Organism:RAT
Description:NR2B Channel Blocker 0 RAT::Q05343
Residue:467
Sequence:
MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLS
SPINGMGPPFSVISSPMGPHSMSVPTTPTLGFETGSPQLNSPMNPVSSSEDIKPPLGLNG
VLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKI
LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS
KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF
AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50133126
n/a
NameBDBM50133126
Synonyms:5-[2-(3,5-Diisopropyl-2-propoxy-phenyl)-cyclopent-1-enyl]-3-methyl-penta-2,4-dienoic acid | CHEMBL133176
TypeSmall organic molecule
Emp. Form.C26H36O3
Mol. Mass.396.5622
SMILESCCCOc1c(cc(cc1C1=C(CCC1)\C=C\C(\C)=C\C(O)=O)C(C)C)C(C)C |t:11|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: