Ki Summary

Reaction Details

Report a problem with these data

Target

Retinoic acid receptor, gamma

Ligand

BDBM50129720

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_196168 (CHEMBL804941)

>1000±n/a nM

Citation

Michellys, PY; Ardecky, RJ; Chen, JH; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Montrose-Rafizadeh, C; Ogilvie, KM; Reifel-Miller, A; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. J Med Chem46:4087-103 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Retinoic acid receptor, gamma

Name:

Retinoic acid receptor, gamma

Synonyms:

Retinoic acid receptor gamma

Type:

PROTEIN

Mol. Mass.:

53686.83

Organism:

Rattus norvegicus

Description:

ChEMBL_196168

Residue:

485

Sequence:

MLALPLPPPGAGHCGGRRGNGLRVLGVLAPSFSPSRVAMYDCMESFVPGPRRLYGAAGPG
AGLLRRATGSSCFAGLESFAWAQPASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVC
NDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEV
GMSKEAVRNDRNKKKKEVKEEGPPDNYELSPQLEELITKVSKAHQETFPSLCQLGKYTTN
SSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILML
RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSA
ICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKG
AERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGSQGKRGQSPQ
PDQGP

BDBM50129720

n/a

Name

BDBM50129720

Synonyms:

(2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid | 7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid | CHEMBL42314

Type

Small organic molecule

Emp. Form.

C25H34F2O3

Mol. Mass.

420.5325

SMILES

C\C(\C=C\C=C(\C)c1cc(cc(c1OCC(F)F)C(C)(C)C)C(C)(C)C)=C/C(O)=O

Structure