Reaction Details |
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Target | Ileal sodium/bile acid cotransporter |
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Ligand | BDBM50134417 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_35875 |
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IC50 | 83±n/a nM |
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Citation | Tollefson, MB; Kolodziej, SA; Fletcher, TR; Vernier, WF; Beaudry, JA; Keller, BT; Reitz, DB A novel class of apical sodium co-dependent bile acid transporter inhibitors: the 1,2-benzothiazepines. Bioorg Med Chem Lett13:3727-30 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Ileal sodium/bile acid cotransporter |
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Name: | Ileal sodium/bile acid cotransporter |
Synonyms: | ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal bile acid transporter | Ileal bile acid transporter/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2 | NTCP2_HUMAN | SLC10A2 |
Type: | Enzyme |
Mol. Mass.: | 37714.89 |
Organism: | Homo sapiens (Human) |
Description: | SLC10A2 |
Residue: | 348 |
Sequence: | MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLG
HIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVD
GDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSL
GFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
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BDBM50134417 |
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n/a |
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Name | BDBM50134417 |
Synonyms: | CHEMBL122229 | {4-[3-((8R,9R)-7,7-Dibutyl-2-dimethylamino-8-hydroxy-6-methyl-5,5-dioxo-6,7,8,9-tetrahydro-5H-5lambda*6*-thia-6-aza-benzocyclohepten-9-yl)-phenylcarbamoyl]-butyl}-triethyl-ammonium; bromide |
Type | Small organic molecule |
Emp. Form. | C37H61N4O4S |
Mol. Mass. | 657.969 |
SMILES | CCCCC1(CCCC)[C@H](O)[C@H](c2cccc(NC(=O)CCCC[N+](CC)(CC)CC)c2)c2cc(ccc2S(=O)(=O)N1C)N(C)C |
Structure |
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