| Reaction Details |
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 | Report a problem with these data |
| Target | Cycloartenol-C-24-methyltransferase |
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| Ligand | BDBM50134728 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_203192 (CHEMBL804437) |
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| IC50 | >100000±n/a nM |
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| Citation |  Magaraci, F; Jimenez, CJ; Rodrigues, C; Rodrigues, JC; Braga, MV; Yardley, V; de Luca-Fradley, K; Croft, SL; de Souza, W; Ruiz-Perez, LM; Urbina, J; Gonzalez Pacanowska, D; Gilbert, IH Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi. J Med Chem46:4714-27 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cycloartenol-C-24-methyltransferase |
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| Name: | Cycloartenol-C-24-methyltransferase |
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| Synonyms: | 24-sterol C-methyltransferase | CPH | SMT1 | SMT1_ARATH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38266.01 |
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| Organism: | Arabidopsis thaliana |
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| Description: | ChEMBL_415082 |
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| Residue: | 336 |
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| Sequence: | MDLASNLGGKIDKSDVLTAVEKYEQYHVFHGGNEEERKANYTDMVNKYYDLATSFYEYGW
GESFHFAQRWKGESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVV
TGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYG
CYKEIYRVLKPGQCFAAYEWCMTDAFDPDNAEHQKIKGEIEIGDGLPDIRLTTKCLEALK
QAGFEVIWEKDLAKDSPVPWYLPLDKNHFSLSSFRLTAVGRFITKNMVKILEYIRLAPQG
SQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE
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| BDBM50134728 |
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| n/a |
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| Name | BDBM50134728 |
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| Synonyms: | (3S,10S,13S,17S)-17-[1-(3-Chloro-pyridin-4-yl)-1-hydroxy-ethyl]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-ol | CHEMBL359216 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H38ClNO2 |
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| Mol. Mass. | 432.038 |
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| SMILES | CC(O)([C@H]1CCC2C3CCC4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)c1ccncc1Cl |
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| Structure | 
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