| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50135301 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_124507 |
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| IC50 | 270±n/a nM |
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| Citation |  Liu, L; Stelmach, JE; Natarajan, SR; Chen, MH; Singh, SB; Schwartz, CD; Fitzgerald, CE; O'Keefe, SJ; Zaller, DM; Schmatz, DM; Doherty, JB SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors. Bioorg Med Chem Lett13:3979-82 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50135301 |
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| n/a |
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| Name | BDBM50135301 |
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| Synonyms: | 1-(2,6-Dichloro-phenyl)-6-phenylsulfanyl-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one | 1-(2,6-dichlorophenyl)-6-(phenylthio)-3,4-dihydropyrido[3,2-d]pyrimidin-2(1H)-one | CHEMBL131176 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13Cl2N3OS |
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| Mol. Mass. | 402.297 |
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| SMILES | Clc1cccc(Cl)c1N1C(=O)NCc2nc(Sc3ccccc3)ccc12 |
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| Structure | 
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