| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-gamma |
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| Ligand | BDBM50135458 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_197090 |
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| Ki | 12±n/a nM |
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| Citation |  Michellys, PY; Boehm, MF; Chen, JH; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Reifel-Miller, A; Ogilvie, KM; Rungta, D; Thompson, AW; Tyhonas, JS; Yumibe, N; Ardecky, RJ Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. Bioorg Med Chem Lett13:4071-5 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-gamma |
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| Name: | Retinoic acid receptor RXR-gamma |
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| Synonyms: | NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50878.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_197216 |
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| Residue: | 463 |
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| Sequence: | MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
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| BDBM50135458 |
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| n/a |
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| Name | BDBM50135458 |
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| Synonyms: | (2E,4E,6E)-7-[3,5-Di-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid | CHEMBL335242 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32F4O3 |
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| Mol. Mass. | 456.5134 |
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| SMILES | C\C(\C=C\C(\F)=C(\C)c1cc(cc(c1OCC(F)(F)F)C(C)(C)C)C(C)(C)C)=C/C(O)=O |
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| Structure | 
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