| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tumor necrosis factor |
|---|
| Ligand | BDBM50570372 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2112058 (CHEMBL4820908) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Natala, SR; Habas, A; Stocking, EM; Orry, A; Price, DL; Gill, MB; Bonhaus, DW; Abagyan, R; Wrasidlo, W Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists. Bioorg Med Chem Lett40:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tumor necrosis factor |
|---|
| Name: | Tumor necrosis factor |
|---|
| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 25645.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P01375 |
|---|
| Residue: | 233 |
|---|
| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
|
|
|
|---|
| BDBM50570372 |
|---|
| n/a |
|---|
| Name | BDBM50570372 |
|---|
| Synonyms: | CHEMBL4865889 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C44H84ClN3O3 |
|---|
| Mol. Mass. | 738.609 |
|---|
| SMILES | Cl.CCCCCCCCCCCCCCOCC(CNC(=O)[C@@H](CCCCN)NCc1ccccc1)OCCCCCCCCCCCCCC |r| |
|---|
| Structure | 
|
|---|
Search and Browse
