| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 2 |
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| Ligand | BDBM50570583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2112584 (CHEMBL4821434) |
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| IC50 | 14130±n/a nM |
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| Citation |  Pasieka, A; Panek, D; Jo?czyk, J; Gody?, J; Sza?aj, N; Latacz, G; Tabor, J; Mezeiova, E; Chantegreil, F; Dias, J; Knez, D; Lu, J; Pi, R; Korabecny, J; Brazzolotto, X; Gobec, S; Höfner, G; Wanner, K; Wi?ckowska, A; Malawska, B Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and ?-aminobutyric acid transporters. Eur J Med Chem218:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 2 |
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| Name: | Sodium- and chloride-dependent GABA transporter 2 |
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| Synonyms: | GABA transporter | GABA transporter 3 | Gabt2 | Gabt3 | Gat-3 | Gat2 | Gat3 | S6A13_MOUSE | Slc6a13 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68283.40 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1460089 |
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| Residue: | 602 |
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| Sequence: | MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQM
IVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENAT
SPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLI
LIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNI
EDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELES
NC
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| BDBM50570583 |
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| n/a |
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| Name | BDBM50570583 |
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| Synonyms: | CHEMBL4862200 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H38N2O |
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| Mol. Mass. | 430.6248 |
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| SMILES | CC(C)(C)CNC[C@@H](O)[C@H](Cc1ccccc1)NCC(c1ccccc1)c1ccccc1 |r| |
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| Structure | 
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