| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
|---|
| Ligand | BDBM50135833 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_69839 (CHEMBL681890) |
|---|
| IC50 | 360±n/a nM |
|---|
| Citation |  Sanders, JM; Gómez, AO; Mao, J; Meints, GA; Van Brussel, EM; Burzynska, A; Kafarski, P; González-Pacanowska, D; Oldfield, E 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem46:5171-83 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Farnesyl pyrophosphate synthase |
|---|
| Name: | Farnesyl pyrophosphate synthase |
|---|
| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48272.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14324 |
|---|
| Residue: | 419 |
|---|
| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
|
|
|
|---|
| BDBM50135833 |
|---|
| n/a |
|---|
| Name | BDBM50135833 |
|---|
| Synonyms: | (2-methylbutyl)aminomethylene-1,1-bisphosphonate | (2-methylbutylamino)methylenediphosphonic acid | (Bis-phosphono-methyl)-(2-methyl-butyl)-ammonium | CHEMBL56011 | [(2-Methyl-butylamino)-phosphono-methyl]-phosphonic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H17NO6P2 |
|---|
| Mol. Mass. | 261.1498 |
|---|
| SMILES | CCC(C)CN=C(P(O)(O)O)P(O)(O)=O |w:5.4| |
|---|
| Structure | 
|
|---|
Search and Browse
