| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
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| Ligand | BDBM25290 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_69840 (CHEMBL681891) |
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| Ki | 46±n/a nM |
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| Citation |  Sanders, JM; Gómez, AO; Mao, J; Meints, GA; Van Brussel, EM; Burzynska, A; Kafarski, P; González-Pacanowska, D; Oldfield, E 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem46:5171-83 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Farnesyl pyrophosphate synthase |
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| Name: | Farnesyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48272.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14324 |
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| Residue: | 419 |
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| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| BDBM25290 |
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| n/a |
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| Name | BDBM25290 |
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| Synonyms: | CHEMBL56073 | bisphosphonate, 39 | {1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosphonopropyl}phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C14H25NO7P2 |
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| Mol. Mass. | 381.2983 |
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| SMILES | CN(CCCCc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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