Reaction Details |
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Target | Eukaryotic translation initiation factor 2-alpha kinase 3 |
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Ligand | BDBM50570971 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2113375 (CHEMBL4822225) |
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IC50 | 75±n/a nM |
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Citation | Calvo, V; Surguladze, D; Li, AH; Surman, MD; Malibhatla, S; Bandaru, M; Jonnalagadda, SK; Adarasandi, R; Velmala, M; Singireddi, DRP; Velpuri, M; Nareddy, BR; Sastry, V; Mandati, C; Guguloth, R; Siddiqui, S; Patil, BS; Chad, E; Wolfley, J; Gasparek, J; Feldman, K; Betzenhauser, M; Wiens, B; Koszelak-Rosenblum, M; Zhu, G; Du, H; Rigby, AC; Mulvihill, MJ Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett43:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Eukaryotic translation initiation factor 2-alpha kinase 3 |
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Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
Synonyms: | E2AK3_HUMAN | EIF2AK3 | HsPEK | PEK | PERK | Pancreatic eIF2-alpha kinase | Pancreatic endoplasmic reticulum kinase (PERK) |
Type: | Enzyme |
Mol. Mass.: | 125190.66 |
Organism: | Homo sapiens (Human) |
Description: | Q9NZJ5 |
Residue: | 1116 |
Sequence: | MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP
AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP
ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES
LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR
TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS
YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE
NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY
YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV
RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE
APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR
SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND
EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF
KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT
AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP
FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN
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BDBM50570971 |
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n/a |
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Name | BDBM50570971 |
Synonyms: | CHEMBL4853611 |
Type | Small organic molecule |
Emp. Form. | C20H17F2N3O2 |
Mol. Mass. | 369.3647 |
SMILES | Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1ccc(N)nc1 |r| |
Structure |
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