| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 2 subunit 1 |
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| Ligand | BDBM50570944 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2113376 (CHEMBL4822226) |
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| IC50 | 307±n/a nM |
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| Citation |  Calvo, V; Surguladze, D; Li, AH; Surman, MD; Malibhatla, S; Bandaru, M; Jonnalagadda, SK; Adarasandi, R; Velmala, M; Singireddi, DRP; Velpuri, M; Nareddy, BR; Sastry, V; Mandati, C; Guguloth, R; Siddiqui, S; Patil, BS; Chad, E; Wolfley, J; Gasparek, J; Feldman, K; Betzenhauser, M; Wiens, B; Koszelak-Rosenblum, M; Zhu, G; Du, H; Rigby, AC; Mulvihill, MJ Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett43:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 2 subunit 1 |
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| Name: | Eukaryotic translation initiation factor 2 subunit 1 |
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| Synonyms: | EIF2A | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha | IF2A_HUMAN | eIF-2-alpha | eIF-2A | eIF-2alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36100.17 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_103542 |
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| Residue: | 315 |
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| Sequence: | MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSIN
KLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLE
YTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNI
NRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTT
TLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEV
DGDDDAEEMEAKAED
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| BDBM50570944 |
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| n/a |
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| Name | BDBM50570944 |
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| Synonyms: | CHEMBL4866245 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N4O2 |
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| Mol. Mass. | 402.4888 |
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| SMILES | CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Cc2ccccc2)cc1C |
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| Structure | 
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