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TargetCyclin-dependent kinase 9
LigandBDBM50570974
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2113477 (CHEMBL4822327)
Kd 1065±n/a nM
Citation King, HMRana, SKubica, SPMallareddy, JRKizhake, SEzell, ELZahid, MNaldrett, MJAlvarez, SLaw, HCWoods, NTNatarajan, A Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax. Bioorg Med Chem Lett43:0 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 9
Name:Cyclin-dependent kinase 9
Synonyms:C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Type:Enzyme Subunit
Mol. Mass.:42789.13
Organism:Homo sapiens (Human)
Description:n/a
Residue:372
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
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  Blast E-value cutoff:
BDBM50570974
n/a
NameBDBM50570974
Synonyms:CHEMBL4846069
TypeSmall organic molecule
Emp. Form.C16H19N3O2
Mol. Mass.285.341
SMILESCOc1ccc(CC(=O)Nc2cc([nH]n2)C2CCC2)cc1
Structure
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