| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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| Ligand | BDBM50136927 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_103130 (CHEMBL712301) |
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| Ki | 500±n/a nM |
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| Citation |  Li, X; Chu, S; Feher, VA; Khalili, M; Nie, Z; Margosiak, S; Nikulin, V; Levin, J; Sprankle, KG; Tedder, ME; Almassy, R; Appelt, K; Yager, KM Structure-based design, synthesis, and antimicrobial activity of indazole-derived SAH/MTA nucleosidase inhibitors. J Med Chem46:5663-73 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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| Name: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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| Synonyms: | 5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA |
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| Type: | Enzyme |
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| Mol. Mass.: | 24347.14 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | P0AF12 |
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| Residue: | 232 |
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| Sequence: | MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGAT
LLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFK
ADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAH
VCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
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| BDBM50136927 |
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| n/a |
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| Name | BDBM50136927 |
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| Synonyms: | 4-Chloro-N-[3-chloro-7-(cyclopropylmethyl-amino)-1H-indazol-5-yl]-benzenesulfonamide | CHEMBL154601 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16Cl2N4O2S |
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| Mol. Mass. | 411.306 |
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| SMILES | Clc1n[nH]c2c(NCC3CC3)cc(NS(=O)(=O)c3ccc(Cl)cc3)cc12 |
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| Structure | 
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