| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage metalloelastase |
|---|
| Ligand | BDBM50137283 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_106462 |
|---|
| IC50 | 57.0±n/a nM |
|---|
| Citation |  Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett14:47-50 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage metalloelastase |
|---|
| Name: | Macrophage metalloelastase |
|---|
| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54012.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P39900 |
|---|
| Residue: | 470 |
|---|
| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
|
|
|
|---|
| BDBM50137283 |
|---|
| n/a |
|---|
| Name | BDBM50137283 |
|---|
| Synonyms: | 6-(benzyloxy)-N-hydroxy-2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide | 6-Benzyloxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide | CHEMBL358539 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H24N2O6S |
|---|
| Mol. Mass. | 468.522 |
|---|
| SMILES | COc1ccc(cc1)S(=O)(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
